Ketanserin tartrate ( R41468 tartrate )

Catalog No. M16108 CAS No. 83846-83-7

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Product Name

Ketanserin tartrate
Note

Research use only, not for human use.
Brief Description

A high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C.
Description

A high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C; also has a high affinity antagonist for the H1 receptor (Ki= 2 nM) and α1-adrenergic receptor (Ki=40 nM); an antihypertensive agent.Hypertension Approved
Synonyms

R41468 tartrate
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Cardiovascular Disease
Indication

Hypertension

CAS Number

83846-83-7
Formula Weight

545.51
Molecular Formula

C26H28FN3O9
Purity

>98% (HPLC)
Solubility

H2O: 30 mg/mL (Need ultrasonic and warming)
SMILES

O=C(N1CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)NC4=C(C=CC=C4)C1=O.O[C@H]([C@H](C(O)=O)O)C(O)=O
Chemical Name

2,4(1H,3H)-Quinazolinedione, 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

1. Creed-Carson M, et al. Behav Brain Res. 2011 Jun 1;219(2):273-9.
2. Catafau AM, et al. J Cereb Blood Flow Metab. 2010 May;30(5):985-93.

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